In 1946 Berlin, an American cop searches for his missing brother while helping a novice German policewoman fight the violent crimes engulfing the city.

A forensic psychiatrist discovers that all but one of her patient's multiple personalities are murder victims. She will have to find out what's happening before her time is finished.

When human forces discover the existence of the Vampire and Lycan clans, a war to eradicate both species commences. The vampire warrior Selene leads the battle against humankind.